Expression of estrogen related proteins in hormone refractory prostate cancer: Association with tumor progression

  • Celhay O
  • Yacoub M
  • Irani J
 et al. 
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Abstract

Purpose Despite increasing evidence that estrogen signaling has a key role in prostate cancer development and progression, few studies have focused on the estrogen pathway in the transition from hormone sensitive to hormone refractory tumors. We investigated the expression of proteins related to androgen and estrogen metabolism in paired prostate cancer samples collected before androgen deprivation therapy and after hormonal relapse. Materials and Methods The study included 55 patients treated for prostate cancer only with androgen deprivation therapy and in whom tissue was available before treatment induction and after recurrence. Immunohistochemistry was performed using tissue microarray with antibodies directed against androgen receptor, phosphorylated androgen receptor, estrogen receptor α, estrogen receptor β, 5α-reductase 1 and 2, aromatase, BCAR1 and the proliferation marker Ki67. Results Compared to hormone sensitive samples, tissues collected after hormonal relapse were characterized by increased expression of Ki67, androgen receptor, phosphorylated androgen receptor (p

Author-supplied keywords

  • Androgen antagonists
  • Estrogens
  • Gene expression
  • Prostate
  • Prostatic neoplasms

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Authors

  • Jacques IraniUniversity Hospitals Southern Paris

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  • Olivier Celhay

  • Mokrane Yacoub

  • Bertrand Dore

  • Olivier Cussenot

  • Gaelle Fromont

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