We have expressed a synthetic gene encoding the insecticidal neurotoxin of scorpion Androctonus australis (AaIT) in NIH/3T3 mouse fibroblast cells under the transcriptional control of a murine retro-viral long terminal repeat. The secretion of the toxin into the culture medium was directed by the signal peptide of human interleukin-2. The recombinant AaIT produced was selectively toxic to yellow-fever mosquito larvae and harmless to mice. © 1990 Nature Publishing Group.
CITATION STYLE
Albert, D., Rama, B. B., Karen, W., Eddie, C., & Mei-Huei, L. L. (1990). Expression and secretion of a functional scorpion insecticidal toxin in cultured mouse cells. Bio/Technology, 8(4), 339–342. https://doi.org/10.1038/ng0490-339
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