Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth

  • Kehat I
  • Davis J
  • Tiburcy M
 et al. 
  • 90

    Readers

    Mendeley users who have this article in their library.
  • 94

    Citations

    Citations of this article.

Abstract

An increase in cardiac afterload typically produces concentric hypertrophy characterized by an increase in cardiomyocyte width, whereas volume overload or exercise results in eccentric growth characterized by cellular elongation and addition of sarcomeres in series. The signaling pathways that control eccentric versus concentric heart growth are not well understood.

Author-supplied keywords

  • MAPK
  • genetically altered mice
  • heart
  • hypertrophy
  • signaling
  • ventricular remodeling

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • izhak kehatTechnion Israel Institute of Technology

    Follow
  • Jennifer Davis

  • Malte Tiburcy

  • Federica Accornero

  • Marc K. Saba-El-Leil

  • Marjorie Maillet

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free