Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth

  • Kehat I
  • Davis J
  • Tiburcy M
 et al. 
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An increase in cardiac afterload typically produces concentric hypertrophy characterized by an increase in cardiomyocyte width, whereas volume overload or exercise results in eccentric growth characterized by cellular elongation and addition of sarcomeres in series. The signaling pathways that control eccentric versus concentric heart growth are not well understood.

Author-supplied keywords

  • MAPK
  • genetically altered mice
  • heart
  • hypertrophy
  • signaling
  • ventricular remodeling

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  • izhak kehatTechnion Israel Institute of Technology

  • Jennifer Davis

  • Malte Tiburcy

  • Federica Accornero

  • Marc K. Saba-El-Leil

  • Marjorie Maillet

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