There is little evidence of the feasibility and acceptability of integrating screening, brief intervention and referral to treatment services that address depression and alcohol, tobacco and other drug (ATOD) use into an-tenatal care in South Africa. Data were extracted from program records on the number of eligible women screened and number meeting criteria for depression and self-re-ported ATOD use. 70 women completed a questionnaire examining their preliminary responses and five MOU personnel were interviewed to identify potential barriers to implementation. Of the 3407 eligible women, 1468 (43 %) women were screened for depression or ATOD use, of whom 302 (21.4 %) screened at risk for depression, 388 (26.4 %) disclosed smoking tobacco, and 29 (2 %) disclosed alcohol or other drugs (AOD). Seventy par-ticipants completed the three month follow-up interview. Depression scores decreased significantly following the intervention (t (69) = 8.51, p \ 0.001) as did self-reported tobacco use (t (73) = 3.45, p \ 0.001), however self-re-ported AOD use remained unchanged.
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