First results of [C]choline PET/CT-guided secondary lymph node surgery in patients with PSA failure and single lymph node recurrence after radical retropubic prostatectomy

  • Winter A
  • Uphoff J
  • Henke R
 et al. 
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Abstract

INTRODUCTION [(11)C]choline PET/CT provides the opportunity to detect small lymph node metastases (LNM) (>5 mm) in prostate cancer (PCa) with exact topographic allocation. PSA development after resection of single LN recurrence detected via [(11)C]choline PET/CT without adjuvant therapy is not yet analyzed. We wanted to evaluate the potential of [(11)C]choline PET/CT in the diagnosis of single LN recurrence after radical prostatectomy (RPE) and whether secondary resection can result in PSA remission. METHODS We investigated 6 patients with biochemical recurrence (PSA: median 2.04, range 0.67-4.51 ng/ml) after RPE. A single suspicious LN was detected on PET/CT without suspicion of local relapse or distant metastasis. The suspicious and nearby LN were open dissected (09/2004-02/2008). Histological and PET/CT findings were compared and the postoperative PSA development was examined. RESULTS All metastasis-suspicious LN could be confirmed histologically. The additionally removed 10 LN were all correctly negative for cancer. Three patients showed a complete permanent PSA remission (

Author-supplied keywords

  • Lymph node recurrence
  • Prostate cancer
  • Prostate-specific antigen relapse
  • Secondary lymph node surgery
  • [ 11C]choline PET/CT

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Authors

  • Alexander Winter

  • Jens Uphoff

  • Rolf Peter Henke

  • Friedhelm Wawroschek

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