Foetal response to maternal coffee intake: Role of habitual versus non-habitual caffeine consumption

  • Mulder E
  • Tegaldo L
  • Bruschettini P
 et al. 
  • 20


    Mendeley users who have this article in their library.
  • 7


    Citations of this article.


Little is known about the effect on the human foetus of long-term and acute exposure to caffeine. We studied the organisation of foetal sleep-wake states in 13 heaLthy near-term foetuses over a wide range of l11atema[ plasma caffeine concentrations (0-13 ~lg/ml) reflecting normal lifestyle conditions (day 0) and again following intake of two cups of regular coffee (-300 mg of caffeine) intermitted by 50 h of abstinence (day 2; acute effects). On either day, 2 h simuLtaneous recordings were made of foetal heart rate, general-, eye-, and breathing-movements. The recordings were analysed for the presence of each of four foetal behavioural states: quiet- and active-sLeep, quiet- and active-wakefulness. There was a linear relationship between maternaL caffeine content and the incidence of foetal general movements durirlg active sleep on day o (R= 0.74; p..;: 0.02). After coffee loading on day 2, foetuses of non- or low-caffeine consumers showed increases in active wakefulness(P..;: 0.001), general movements (P..;: 0.05) and heart rate variation (P

Author-supplied keywords

  • adenosine receptor
  • behavioural states
  • caffeine
  • coffee
  • foetus
  • pregnancy
  • wakefulness

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • E. J.H. Mulder

  • L. Tegaldo

  • P. Bruschettini

  • G. H.A. Visser

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free