A deprotonated 2-imidazoline-4(5)-one product ion was observed as a major fragment in the collisioninduced dissociation (CID) of several dipeptides containing serine at the C-terminal and an amino acid with an alkyl substituent at the N-terminal. This fragment becomes predominant at high collision energies. The same type of product ion was seen in the CID of cyclo(GlyGly). Labeling GlySer with O-18 suggests that the fragmentation may proceed through a symmetrical intermediate such as a deprotonated diketopiperazine. Density functional theory calculations of GlySer provided a possible mechanism for the fragmentation.
CITATION STYLE
Swan, J. S., Findeis, P. M., Hilton, S., Lebold, K. M., Temelso, B., & Shields, G. C. (2015). Formation of deprotonated 2-imidazoline-4(5)-one product ions in the collision-induced dissociation of some serine-containing dipeptides. International Journal of Mass Spectrometry, 381–382(1), 25–32. https://doi.org/10.1016/j.ijms.2015.03.005
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