Fragile X is a synapsopathy - a disorder of synaptic function and plasticity. Recent studies using mouse models of the disease suggest that the critical defect is altered regulation of synaptic protein synthesis. Various strategies to restore balanced synaptic protein synthesis have been remarkably successful in correcting widely varied mutant phenotypes in mice. Insights gained by the study of synaptic plasticity in animal models of fragile X have suggested novel therapeutic approaches, not only for human fragile X but also for autism and mental retardation of unknown etiology. © 2008 Nature Publishing Group All rights reserved.
CITATION STYLE
Bear, M. F., Dölen, G., Osterweil, E., & Nagarajan, N. (2008, January). Fragile X: Translation in action. Neuropsychopharmacology. https://doi.org/10.1038/sj.npp.1301610
Mendeley helps you to discover research relevant for your work.