Functional identification of an aggression locus in the mouse hypothalamus

  • Lin D
  • Boyle M
  • Dollar P
 et al. 
  • 839

    Readers

    Mendeley users who have this article in their library.
  • 323

    Citations

    Citations of this article.

Abstract

Electrical stimulation of certain hypothalamic regions in cats and rodents can elicit attack behaviour, but the exact location of relevant cells within these regions, their requirement for naturally occurring aggression and their relationship to mating circuits have not been clear. Genetic methods for neural circuit manipulation in mice provide a potentially powerful approach to this problem, but brain-stimulation-evoked aggression has never been demonstrated in this species. Here we show that optogenetic, but not electrical, stimulation of neurons in the ventromedial hypothalamus, ventrolateral subdivision (VMHvl) causes male mice to attack both females and inanimate objects, as well as males. Pharmacogenetic silencing of VMHvl reversibly inhibits inter-male aggression. Immediate early gene analysis and single unit recordings from VMHvl during social interactions reveal overlapping but distinct neuronal subpopulations involved in fighting and mating. Neurons activated during attack are inhibited during mating, suggesting a potential neural substrate for competition between these opponent social behaviours.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Ed LeinAllen Institute for Brain Science

    Follow
  • Dayu Lin

  • Maureen P. Boyle

  • Piotr Dollar

  • Hyosang Lee

  • Pietro Perona

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free