A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han

  • K. W
  • H. G
  • H. H
 et al. 
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MicroRNAs (miRNAs) are small, non-protein-coding RNAs that function as tumour suppressors or oncogenes. A single nucleotide change in the sequence of pre-miRNA can affect miRNA expression, so single-nucleotide polymorphisms (SNPs) in pre-miRNA may be biomarkers for biomedical applications. In this study, we performed a genetic association study between the SNP (rs11614913) in pre-miRNA-196a and esophageal squamous cell carcinoma (ESCC) susceptibility in a case-control study. We found that the homozygote CC of this SNP increased the risk of ESCC compared with the homozygote TT and the risk was more evident among smokers than non-smokers. Therefore, this functional SNP may be a biomarker for ESCC outcome. © 2010 Informa UK, Ltd.

Author-supplied keywords

  • *esophagus carcinoma
  • Chinese
  • adult
  • article
  • cancer risk
  • cancer susceptibility
  • controlled study
  • female
  • gene amplification
  • genetic association
  • homozygosity
  • human
  • major clinical study
  • male
  • microRNA/ec [Endogenous Compound]
  • single nucleotide polymorphism
  • smoking
  • squamous cell carcinoma

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  • Wang K.

  • Guo H.

  • Hu H.

  • Xiong G.

  • Guan X.

  • Li J.

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