We have developed a rapid, simple and precise gas chromatographic headspace analysis for sevoflurane in blood which circumvents problems associated with the high volatility and low blood/gas partition coefficient of this anesthetic drug. Blood standards are easily prepared by volumetric addition of a saturated aqueous solution of sevoflurane. Likewise, internal standardization is achieved using a saturated aqueous solution of halothane. Chromatographic conditions are similar to those commonly used for the analysis of blood ethanol. A simple method is also described for the preparation of stable and precise aliquots of quality control materials for this assay. © 1992.
CITATION STYLE
Watts, M. T., Escarzaga, M., & Williams, C. H. (1992). Gas chromatographic headspace analysis of sevoflurane in blood. Journal of Chromatography B: Biomedical Sciences and Applications, 577(2), 289–298. https://doi.org/10.1016/0378-4347(92)80250-T
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