Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease

  • Bilsborough J
  • Viney J
  • 51

    Readers

    Mendeley users who have this article in their library.
  • 97

    Citations

    Citations of this article.

Abstract

Discrimination between beneficial commensal organisms and potentially harmful pathogens is a central component of the essential role that gut immune cells play in maintaining the balance between immune activation and tolerance. Antigen presenting cells (APC) are the key to this process, and the type of APC, including epithelial cells, B cells, macrophages, and dendritic cells (DC), in the gut is varied. The purpose of this review is to focus on the vast amount of data that has recently been generated on gastrointestinal dendritic cells in the context of their potential function and contribution to mucosal immunity, tolerance, and disease.

Author-supplied keywords

  • APC
  • DC
  • MLN
  • PLN
  • antigen presenting cells
  • dendritic cells
  • mesenteric lymph nodes
  • peripheral lymph nodes

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Janine Bilsborough

  • Joanne L. Viney

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free