Generating protein interaction maps from incomplete data: Application to fold assignment

  • Lappe M
  • Park J
  • Niggemann O
 et al. 
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Abstract

We present a framework to generate comprehensive overviews of protein-protein interactions. In the post-genomic view of cellular function, each biological entity is seen in the context of a complex network of interactions. Accordingly, we model functional space by representing protein-protein-interaction data as undirected graphs. We suggest a general approach to generate interaction maps of cellular networks in the presence of huge amounts of fragmented and incomplete data, and to derive representations of large networks which hide clutter while keeping the essential architecture of the interaction space. This is achieved by contracting the graphs according to domain-specific hierarchical classifications. The key concept here is the notion of induced interaction, which allows the integration, comparison and analysis of interaction data from different sources and different organisms at a given level of abstraction.

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Authors

  • Michael Lappe

  • Jong Park

  • Oliver Niggemann

  • Liisa Holm

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