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Genetic architecture of Hsp90-dependent drug resistance

Eukaryotic Cell (2006) 5(12) 2184-2188
DOI: 10.1128/EC.00274-06
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Abstract

Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

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Cowen, L. E., Carpenter, A. E., Matangkasombut, O., Fink, G. R., & Lindquist, S. (2006). Genetic architecture of Hsp90-dependent drug resistance. Eukaryotic Cell, 5(12), 2184–2188. https://doi.org/10.1128/EC.00274-06

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