Genetic diversity of LEE genes of enteropathogenic

  • Contreras C
  • Ochoa T
  • Ruiz J
 et al. 
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Abstract

The aim of this study was to determine the frequency and allele-associations of LEE encoded esp and tir genes among 181 EPEC strains (90 diarrhea-associated and 91 controls) isolated from Peruvian children less than 18 months of age. We have analyzed espA, espB, espD and tir alleles by PCRRFLP. EPEC strains were isolated with higher frequency from healthy controls (92/424, 21.7%) than from diarrheal samples (90/936, 9.6%) (p< 0.001); 28.9% of diarrheal and 17.6% of control samples were typical EPEC (tEPEC). The distribution of espA-alleles (alpha, beta, beta2 and gamma) and espD-alleles (alpha, beta, gamma and a new variant,espD-N1) between tEPEC and atypical EPEC (aEPEC) was significantly different (p< 0.05). espD-alpha was more common among acute episodes (p

Author-supplied keywords

  • Enteric infections
  • Epidemiological typing
  • Molecular epidemiology
  • Sequence typing
  • Virulence
  • factors

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Authors

  • Carmen A Contreras

  • Theresa J Ochoa

  • Joaquin Ruiz

  • David W Lacher

  • David Durand

  • Claudio F Lanataand Thomas G Cleary

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