If a CRC declined to participate, did not respond, or withdrew from our study after agreeing to participate, we replaced it with the next-largest CRC at the same institution (if one existed). Because we found no readily accessible information about the relative size of SPOREs and because some institutions have several SPOREs, we randomly selected one SPORE from the institutions that had more than one. [...] without explicit procedures for coding biological materials, investigators may omit steps that are necessary to protect the confidentiality of research data.
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