Germ layer induction from embryonic stem cells

  • Gadue P
  • Huber T
  • Nostro M
 et al. 
  • 135

    Readers

    Mendeley users who have this article in their library.
  • 88

    Citations

    Citations of this article.

Abstract

Embryonic stem (ES) cells have the potential to develop into all cell types of the adult body. This capability provides the basis for considering the ES cell system as a novel and unlimited source of cells for replacement therapies for the treatment of a wide range of diseases. Before the cell-based therapy potential of ES cells can be realized, a better understanding of the pathways regulating lineage-specific differentiation is required. Current studies suggest that the bone morphogenic protein, transforming growth factor-β, Wnt, and fibroblast growth factor pathways that are required for gastrulation and germ layer induction in the embryo are also essential for differentiation of ES cells in culture. The current understanding of how these factors influence germ layer induction in both the embryo and in the ES cell differentiation system is addressed in this review. © 2005 International Society for Experimental Hematology. Published by Elsevier Inc.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Paul Gadue

  • Tara L. Huber

  • M. Cristina Nostro

  • Steven Kattman

  • Gordon M. Keller

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free