Get to grips: Steering local actin dynamics with IQGAPs

  • Brandt D
  • Grosse R
  • 85


    Mendeley users who have this article in their library.
  • 99


    Citations of this article.


IQGAPs are actin-binding proteins that scaffold numerous interaction partners, transmitting extracellular signals that influence mitogenic, morphological and migratory cell behaviour. However, the precise mechanisms by which IQGAP proteins influence actin dynamics and actin filament structures have been elusive. Now that IQGAP1 has emerged as a potential key regulator of actin-cytoskeletal dynamics by recruiting both the actin related protein (Arp)2/3 complex and/or formin-dependent actin polymerizing machineries, we propose that IQGAP1 might coordinate the function of mechanistically different actin nucleators for cooperative localized actin filament production in various cellular processes.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Dominique T. Brandt

  • Robert Grosse

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free