HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature

  • Handa S
  • Andersson M
  • Gallou F
 et al. 
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Abstract

The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2 , enables Pd-catalyzed cross-couplings to be run using ?1000 ppm of this pre-catalyst. Applications to Suzuki– Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures. Com- parisons with existing state-of-the-art ligands and catalysts are discussed herein.

Author-supplied keywords

  • E Factor
  • Suzuki-Miyaura coupling
  • green chemistry
  • ligand design
  • micellar catalysis

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Authors

  • Sachin Handa

  • Martin P. Andersson

  • Fabrice Gallou

  • John Reilly

  • Bruce H. Lipshutz

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