Hematologic malignancies and Klinefelter syndrome: A chance association?

  • Keung Y
  • Buss D
  • Chauvenet A
 et al. 
  • 12


    Mendeley users who have this article in their library.
  • 35


    Citations of this article.


Klinefelter syndrome was first described in 1942 as an endocrine disorder characterized by gynecomastia, hypogonadism, small testes, and elevated levels of follicle-stimulating hormone. An extra X chromosome (i.e., 47,XXY) was subsequently demonstrated in these patients and an increased incidence of leukemia and lymphoma has been described. We report a retrospective study of a series of unselected patients with Klinefelter syndrome diagnosed by cytogenetic studies and the occurrence of hematologic malignancies. The literature is also reviewed. © 2002 Elsevier Science Inc. All rights reserved.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Yi Kong Keung

  • David Buss

  • Allen Chauvenet

  • Mark Pettenati

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free