Hematologic malignancies and Klinefelter syndrome: A chance association?

  • Keung Y
  • Buss D
  • Chauvenet A
 et al. 
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Abstract

Klinefelter syndrome was first described in 1942 as an endocrine disorder characterized by gynecomastia, hypogonadism, small testes, and elevated levels of follicle-stimulating hormone. An extra X chromosome (i.e., 47,XXY) was subsequently demonstrated in these patients and an increased incidence of leukemia and lymphoma has been described. We report a retrospective study of a series of unselected patients with Klinefelter syndrome diagnosed by cytogenetic studies and the occurrence of hematologic malignancies. The literature is also reviewed. © 2002 Elsevier Science Inc. All rights reserved.

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Authors

  • Yi Kong Keung

  • David Buss

  • Allen Chauvenet

  • Mark Pettenati

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