Klinefelter syndrome was first described in 1942 as an endocrine disorder characterized by gynecomastia, hypogonadism, small testes, and elevated levels of follicle-stimulating hormone. An extra X chromosome (i.e., 47,XXY) was subsequently demonstrated in these patients and an increased incidence of leukemia and lymphoma has been described. We report a retrospective study of a series of unselected patients with Klinefelter syndrome diagnosed by cytogenetic studies and the occurrence of hematologic malignancies. The literature is also reviewed. © 2002 Elsevier Science Inc. All rights reserved.
CITATION STYLE
Keung, Y. K., Buss, D., Chauvenet, A., & Pettenati, M. (2002). Hematologic malignancies and Klinefelter syndrome: A chance association? Cancer Genetics and Cytogenetics, 139(1), 9–13. https://doi.org/10.1016/S0165-4608(02)00626-X
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