A highly selective DNAzyme sensor for mercuric ions

  • Hollenstein M
  • Hipolito C
  • Lam C
 et al. 
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Abstract

(Figure Presented) The mercury project: A self-cleaving DNAzyme that "switches on" in the presence of Hg2+ has been revealed by in vitro selection. The enzyme 10-13 (see picture) utilizes two modified nucleobases to confer an RNaseA-like catalytic activity that requires only Hg2+ and no other divalent metal cofactor. This DNAzyme is highly selective for mercuric cations. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Author-supplied keywords

  • DNA
  • Enzyme catalysis
  • Mercury
  • Nucleic acids
  • Sensors

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