A large fraction of HLA class I, and possibly class II, molecules can be classified into relatively few supertypes, characterized by overlapping peptide-binding repertoires and consensus B- and F-pocket structures. Cross-binding peptides are frequently recognized by specific T cells in the course of natural disease processes and in the context of multiple HLA molecules, validating the concept of HLA supertypes at the functional level.
CITATION STYLE
Sette, A., & Sidney, J. (1998). HLA supertypes and supermotifs: A functional perspective on HLA polymorphism. Current Opinion in Immunology, 10(4), 478–482. https://doi.org/10.1016/S0952-7915(98)80124-6
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