Human MAFA has alternatively spliced variants

  • Lamers M
  • Lamont A
  • Williams D
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Abstract

Human mast cell function-associated antigen (MAFA) cDNA has been cloned. This molecule is similar to the rat form having an intracellular domain containing a putative immunoreceptor tyrosine inhibition motif and an extracellular C type lectin-like domain. However, in contrast to rat MAFA, the amino acid sequence suggests the presence of two additional extracellular N-linked glycosylation sites. In addition, alternative mRNA transcripts are observed that differ substantially from those found in the rat.

Author-supplied keywords

  • Exon
  • Immunoreceptor tyrosine inhibition motif
  • Mast cell
  • Mast cell function-associated antigen
  • Transcript

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Authors

  • Marieke B.A.C. Lamers

  • Alan G. Lamont

  • David H. Williams

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