Ibuprofen use during extreme exercise: Ef... & related info

Ibuprofen use during extreme exercise: Effects on oxidative stress and PGE2

McAnulty S
Owens J
McAnulty L

et al.

Medicine and Science in Sports and Exercise (2007) 39(7) 1075-1079

31
Readers
Mendeley users who have this article in their library.
33
Citations
Citations of this article.

Abstract

PURPOSE: Oxidative stress was examined with use (N = 29) or nonuse (N = 25) of ibuprofen in ultramarathoners after the Western States Endurance Run. METHODS: Oxidative stress was assessed by measuring plasma and urinary F2-isoprostanes, plasma nitrite, and plasma urate. A urinary prostaglandin E2 metabolite (PGE-M) was used as an end point to assess ibuprofen use. Ibuprofen users consumed 600 and 1200 mg of ibuprofen the day before and on race day, respectively, and nonusers avoided all antiinflammatory medications. Blood and urine were collected in the morning before the race and immediately after the race. RESULTS: Use compared with nonuse of ibuprofen significantly increased plasma (P