Identifying the needs of penile cancer sufferers: a systematic review of the quality of life, psychosexual and psychosocial literature in penile cancer.

  • Pietrzak P
  • Corbishley C
  • Watkin N
 et al. 
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Abstract

There is evidence that a subset of penile carcinomas is caused by infection with high-risk human papillomavirus (HPV). However, extensive studies on the possible influence of HPV infection on clinical outcome of penile cancer are lacking. This investigation is aimed to examine the prevalence of high-risk HPV in a large series of penile squamous-cell carcinomas (SCCs) and to determine the relationship between HPV and survival. Formalin-fixed, paraffin-embedded tumor specimens of 171 patients with penile carcinoma were tested for high-risk HPV DNA presence by GP5+/6+-PCR. The clinical course of the patients and the histopathological characteristics of the primary tumors were reviewed. High-risk HPV DNA was detected in 29% of the tumors, with HPV 16 being the predominant type, accounting for 76% of high-risk HPV containing SCCs. Disease-specific 5-year survival in the high-risk HPV-negative group and high-risk HPV-positive group was 78% and 93%, respectively (log rank test p = 0.03). In multivariate analysis, the HPV status was an independent predictor for disease-specific mortality (p = 0.01) with a hazard ratio of 0.14 (95% CI: 0.03-0.63). Our results indicate that the presence of high-risk HPV (29%) confers a survival advantage in patients with penile carcinoma.

Author-supplied keywords

  • 80 and over
  • Adult
  • Aged
  • Assessment
  • Body Image
  • Carcinoma
  • Carcinoma in situ
  • Cervical cancer
  • Chemotherapy
  • Circumcision
  • Clinicaloutcomes
  • Clinicopathological
  • Common factor analysis
  • Confirmatory factor analysis
  • Conservative surgery
  • Erectile Dysfunction
  • Erythroplasia of Queyrat
  • Factor indeterminacy
  • Flat penile lesions
  • Follow-Up Studies
  • Follow-up recommendations
  • Genital Afferent Neurophysiology
  • Genital Bowen's disease
  • Glans preservation
  • Glans resurfacing
  • Glansectomy
  • HPV
  • Human papillomavirus
  • Humans
  • Lasers
  • Lichen sclerosis
  • Life satisfaction
  • Lymph node dissection
  • Lymph nodes
  • Lymphadenectomy
  • Male
  • Male: methods
  • Management
  • Medical history
  • Micturition
  • Middle Aged
  • Molecular pathogenesis
  • Morbidity
  • Neoplasm Invasiveness
  • Outcome assessment (health care)
  • Penile Anatomy
  • Penile Cancer
  • Penile Diseases
  • Penile Diseases: surgery
  • Penile Neoplasms
  • Penile Neoplasms: surgery
  • Penile cancer
  • Penile carcinoma
  • Penile intraepithelial neoplasia
  • Penile neoplasms
  • Penile surgery
  • Penis
  • Penis Size Shame
  • Penis: surgery
  • Phallus preservation strategies
  • Postoperative complications
  • Prevention
  • Prospective Studies
  • Radiotherapy
  • Reconstructive Surgical Procedures
  • Reconstructive Surgical Procedures: methods
  • Recurrence
  • Relative efficiency
  • Retrospective Studies
  • Risk factors
  • Sentinel lymph node biopsy
  • Sexual Reflex
  • Sexual activity
  • Small Penis Syndrome
  • Smegma
  • Squamous Cell
  • Squamous Cell: surgery
  • Squamous cell carcinoma
  • Surgery
  • Surgical limit
  • Survival
  • Tanzania
  • Transitional Cell
  • Transitional Cell: surgery
  • Treatment
  • Treatment Outcome
  • Treatment outcome
  • Treatment-seeking
  • Urethra
  • Urethra: surgery
  • Urogenital Surgical Procedures
  • Urogenital Surgical Procedures: methods
  • Urologic Surgical Procedures
  • Urologic cancer
  • Vibratory Stimulation
  • Wound complications
  • amputation
  • body image and sexuality
  • brachytherapy
  • cancer
  • carcinoma
  • clinicopathological
  • com
  • correspondence
  • drphillipoleo
  • glansectomy
  • incidence
  • lymph nodes
  • lymphadenectomy
  • organ preservation
  • organ sparing
  • organ sparing treatments
  • penectomy
  • penile cancer
  • penile carcinoma
  • penis
  • phalloplasty
  • physiological
  • population-based
  • prognosis
  • prognostic
  • qualitative approaches
  • quality of life
  • questionnaire
  • questionnaires
  • rehabilitation
  • review
  • sexual dysfunction
  • sexual function
  • sexuality
  • split-thickness skin graft
  • squamous cell
  • staging
  • surgery
  • survival analysis
  • tanzania
  • tnm
  • treatment
  • treatment outcome
  • yahoo

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Authors

  • Peter Pietrzak

  • Cathy Corbishley

  • Nicholas a. Nick a. Watkin

  • Enzo Palminteri

  • Elisa Berdondini

  • Massimo Lazzeri

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