Immunogenicity and safety of a pertussis vaccine composed of pertussis toxin inactivated by hydrogen peroxide, in 18- to 23-month-old children

  • Krantz I
  • Sekura R
  • Trollfors B
 et al. 
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Abstract

A new pertussis vaccine, composed of purified pertussis toxin inactivated by hydrogen peroxide and adsorbed onto aluminum hydroxide (NICHD-Ptxd), was injected into 60 children aged 18 to 23 months without a history of pertussis or pertussls vaccination. Two doses of toxoid, 10 and 50 μg, were used. Two injections, given 8 to 12 weeks apart,ellcited increases in serum levels of antitoxin and IgG antibodies in 56 children who had no detectable antitoxin (-5 units) before the first vaccination had pronounced antibody increases after the first dose. After the second dose, the geometric mean antitoxin concentration was 29 units with the 50 μg dosage and 10 units with the 10 μg dosage (p

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Authors

  • Ingela Krantz

  • Ronald Sekura

  • Birger Trollfors

  • John Taranger

  • Gunilla Zackrisson

  • Teresa Lagergard

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