Impact of paravalvular leakage on outcome in patients after transcatheter aortic valve implantation

  • Vasa-Nicotera M
  • Sinning J
  • Chin D
 et al. 
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Objectives The aim of this study was to evaluate the performance of the aortic regurgitation (AR) index as a new hemodynamic parameter in an independent transcatheter aortic valve implantation (TAVI) cohort and validate its application. Background Increasing evidence associates more-than-mild periprosthetic aortic regurgitation (periAR) with increased mortality and morbidity; therefore precise evaluation of periAR after TAVI is essential. The AR index has been proposed recently as a simple and reproducible indicator for the severity of periAR and predictor of associated mortality. Methods The severity of periAR was evaluated by echocardiography, angiography, and periprocedural measurement of the dimensionless AR index = ([diastolic blood pressure - left ventricular end-diastolic pressure]/systolic blood pressure) × 100. A cutoff value of 25 was used to identify patients at risk. Results One hundred twenty-two patients underwent TAVI by use of either the Medtronic CoreValve (Medtronic, Minneapolis, Minnesota) (79.5%) or the Edwards-SAPIEN bioprosthesis (Edwards Lifesciences, Irvine, California) (20.5%). The AR index decreased stepwise from 29.4 ± 6.3 in patients without periAR (n = 26) to 28.0 ± 8.5 with mild periAR (n = 76), 19.6 ± 7.6 with moderate periAR (n = 18), and 7.6 ± 2.6 with severe periAR (n = 2) (p < 0.001). Patients with AR index

Author-supplied keywords

  • CoreValve
  • Edwards-SAPIEN
  • TAVI
  • paravalvular leakage
  • periprosthetic aortic regurgitation

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  • Mariuca Vasa-Nicotera

  • Jan Malte Sinning

  • Derek Chin

  • Tiong Keng Lim

  • Tomasz Spyt

  • Hasan Jilaihawi

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