Increased risk of breast cancer development after diagnosis of salivary gland tumour.

  • In der Maur C
  • Klokman W
  • van Leeuwen F
 et al. 
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The aim of this study was to evaluate whether patients with salivary gland tumours are at increased risk of developing breast cancer. A retrospective cohort study was performed. Female patients (n = 439) with a salivary gland tumour (major and minor) were included. The diagnosis was confirmed histologically. The median follow-up was 5.4 years. Fifteen patients out of 439 with a salivary gland tumour subsequently developed breast cancer, with a mean time interval of 64 months. On the basis of incidence rates in the general population 5.93 breast cancers would be expected. The standardised incidence ratio (SIR) was 2.5 (95% confidence interval: 1.4-4.2; P = 0.003). Increased SIRs were also observed for other solid malignancies, but the numbers were small (n < 5). It is concluded that female patients with a salivary gland tumour have a 2.5 times increased risk of developing breast cancer. Breast screening of these patients is therefore recommended.

Author-supplied keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms
  • Breast Neoplasms: epidemiology
  • Epidemiologic Methods
  • Female
  • Humans
  • Incidence
  • Middle Aged
  • Neoplasms, Second Primary
  • Neoplasms, Second Primary: epidemiology
  • Netherlands
  • Netherlands: epidemiology
  • Salivary Gland Neoplasms
  • Salivary Gland Neoplasms: epidemiology

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  • Caroline D In der Maur

  • Willem J Klokman

  • Floor E van Leeuwen

  • I Bing Tan

  • Emiel J Th Rutgers

  • Alfons J M Balm

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