Increment of interleukin 6, tumour necrosis factor alpha, nitric oxide, C-reactive protein and apoptosis in dengue

  • Levy A
  • Valero N
  • Espina L
 et al. 
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Abstract

This study evaluated the levels of TNFα, IL-6, IL-1β, nitric oxide (NO), CRP, C3 and apoptosis in 36 patients with dengue fever (DF), 34 patients with dengue haemorrhagic fever (DHF) and in virus-infected monocyte cultures. IL-6, TNFα, NO (nitrites) and CRP levels were increased and C3 diminished in patients with DF and DHF. IL-6, TNFα, CPR and C3 values were associated with disease severity (DHF). Nitrite content was incremented in DF patients. TNFα, NO and CRP levels were associated with secondary infection. IL-6 and CRP levels were associated with dengue virus type 4 (DENV-4) and DENV-2, respectively. Low levels of C3 were associated with DENV-2 and DENV-4 infections. Similarly, increased content of TNFα, IL-6 and nitrites were observed in supernatants from infected monocyte cultures. IL-6 was associated with DENV-4 infection. The different virus serotypes induced apoptosis in monocyte cultures. Dengue infection did not induce elevated IL-1β production, either in patients or in infected cultures. These results suggest that TNFα, IL-6, NO and CRP are involved in dengue infection and that monocytes could be an important source of cytokine and NO production. © 2009 Royal Society of Tropical Medicine and Hygiene.

Author-supplied keywords

  • Apoptosis
  • Complement
  • Cytokines
  • Dengue
  • Monocytes
  • Venezuela

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Authors

  • Alegria Levy

  • Nereida Valero

  • Luz Marina Espina

  • Germán Añez

  • Julia Arias

  • Jesús Mosquera

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