A novel NMR scheme is presented that establishes homonuclear spin correlations without requiring direct detection of the spin species. This covariance NMR method is experimentally demonstrated for a mixture of amino acids and for the uniformly 13C-labeled cyclic decapeptide antamanide using a 13C-edited TOCSY experiment. The method opens up new avenues for the experimental analysis of molecules containing insensitive spins encountered in biomolecular NMR and analytical chemistry including metabolomics. Copyright © 2004 American Chemical Society.
CITATION STYLE
Zhang, F., & Brüschweiler, R. (2004). Indirect covariance NMR spectroscopy. Journal of the American Chemical Society, 126(41), 13180–13181. https://doi.org/10.1021/ja047241h
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