Induction and maintenance of in vivo ventricular fibrillation in rabbits

  • Oriente V
  • Koike M
  • Coutinho M
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • 1


    Citations of this article.


Aim: To provide new sustainable in vivo models of ventricular fibrillation in rabbits. Methods: New Zealand rabbits were submitted to anaesthesia and mechanical ventilation, after which ventricular fibrillation was induced through electrical stimulation (for 2 min at 100 Hz, with 2-ms pulses, 10 mA, and 10 V) directly to the heart. To that end, the animals were divided into two groups: right ventricle (n = 11) and left ventricle (n = 11). In group right ventricle, the thoracic cavity was exposed, and a catheter was introduced into the right ventricle via the right jugular vein. In group left ventricle, the thorax remained closed, and the catheter was introduced into the left ventricle via the left common carotid artery (cervical access). Results: Sustained ventricular fibrillation was achieved in 100% of group right ventricle rabbits (n = 11) and in 82% of group left ventricle rabbits (n = 9). Conclusion: Both models proved appropriate for achieving sustained ventricular fibrillation. However, in view of the invasiveness of the procedure adopted in group right ventricle, the experimental conditions used in group left ventricle seemed more physiological and more effective in inducing sustained ventricular fibrillation. © 2009 Elsevier Ireland Ltd. All rights reserved.

Author-supplied keywords

  • Electrocardiography
  • Ventricular arrhythmia
  • Ventricular fibrillation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Marcia KoikeUniversidade de Sao Paulo

  • Victor Oriente

  • Meriangela Pereira Coutinho

  • Irineu Tadeu Velasco

  • Augusto Scalabrini-Neto

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free