Inflammation and metabolic disorders 1

  • Hotamisligil G
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Abstract

Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare

Author-supplied keywords

  • 1
  • Adipose Tissue
  • Animals
  • Cardiovascular
  • Chronic
  • DISEASE
  • DYSFUNCTION
  • Dependent
  • Diabetes Mellitus
  • Extramural
  • Genetic
  • Human
  • Humans
  • Inflammation
  • Insulin Resistance
  • Massachusetts
  • Metabolic Syndrome X
  • Obesity
  • PATHWAY
  • Research Support
  • Support
  • Type 2
  • complications
  • drug therapy
  • genetics
  • immunology
  • metabolism
  • pathology

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Authors

  • Gökhan S. Hotamisligil

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