Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison

  • Nutakul W
  • Sobers H
  • Qiu P
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The effects of resveratrol and pterostilbene (two structurally related stilbene compounds) on three human colon cancer cells were systematically compared. Cell viability tests indicated that IC(50) values of pterostilbene were 2-5-fold lower than those of resveratrol in all three cancer cells. Pterostilbene was also more potent in inhibiting colony formation of all three cancer cells. Annexin V/propidium iodide costaining assay and Western blotting analysis showed pterostilbene had a stronger apoptosis-inducing effect, which was evidenced by the higher percentage of annexin V positive cells and higher levels of cleaved caspase-3 and poly(ADP-ribose) polymerase proteins in cancer cells treated with pterostilbene compared with resveratrol. High-performance liquid chromatography analysis demonstrated that intracellular levels of pterostilbene were 2-4-fold higher than those of resveratrol after treatments with individual compounds at the same concentration. Overall, the results demonstrated that pterostilbene had more potent inhibitory effects on colon cancer cells than resveratrol, which may be associated with the superior bioavailability of pterostilbene to resveratrol.

Author-supplied keywords

  • *Antineoplastic Agents
  • Annexin A5/analysis
  • Apoptosis/drug effects
  • Caco-2 Cells
  • Cell Survival/drug effects
  • Colonic Neoplasms/chemistry/*pathology
  • HCT116 Cells
  • HT29 Cells
  • Humans
  • Stilbenes/analysis/chemistry/*pharmacology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • W Nutakul

  • H S Sobers

  • P Qiu

  • P Dong

  • E A Decker

  • D J McClements

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free