Summary Over the last 5 years, the Chronic Kidney Disease in Children (CKiD) prospective cohort study has enrolled close to 600 children ages 1 to 16 years with mild to moderate chronic kidney disease (CKD). The main pur- pose of this interim report is to review the initial cross-sectional data and conclusions derived from the clini- cal studies conducted within CKiD in the context of findings from other pediatric CKD and end-stage renal disease (ESRD) registry and cohort studies. In particular, special emphasis was placed on studying four as- pects of chronic kidney disease in children, including the identification of risk factors related to disease pro- gression, the impact of CKD on neurocognition and quality of life (QoL), the cardiovascular morbidity associ- ated with CKD, and identifying the causes and effects of growth failure in the context of mild to moderate kidney failure.
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