In-situ Fabrication of Dialysis Membranes in Glass Microchannels Using Laser-induced Phase-Separation Polymerization

Abstract

Laser-induced phase-sepn. polymn. of a porous acrylate polymer is used for in-situ fabrication of dialysis membranes inside glass microchannels. A shaped 355 nm laser beam is used to define polymer membranes of 4-14 mm thickness, which bond to the glass microchannel and form a semipermeable membrane. Differential diffusion through the membrane is obsd. for fluorescein mols. vs. 200 nm latex microspheres, showing the potential for this technique to integrate sample cleanup into chip-based anal. systems. [on SciFinder (R)]