Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood

  • Bennett L
  • Palucka A
  • Arce E
 et al. 
  • 261


    Mendeley users who have this article in their library.
  • 1.2k


    Citations of this article.


Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity. Using oligonucleotide microarrays, we now show that active SLE can be distinguished by a remarkably homogeneous gene expression pattern with overexpression of granulopoiesis-related and interferon (IFN)-induced genes. Using the most stringent statis-tical analysis (Bonferroni correction), 15 genes were found highly up-regulated in SLE pa-tients, 14 of which are targets of IFN and one, defensin DEFA-3, a major product of imma-ture granulocytes. A more liberal correction (Benjamini and Hochberg correction) yielded 18 additional genes, 12 of which are IFN-regulated and 4 granulocyte-specific. Indeed immature neutrophils were identified in a large fraction of SLE patients white blood cells. High dose glucocorticoids, a standard treatment of disease flares, shuts down the interferon signature, fur-ther supporting the role of this cytokine in SLE. The expression of 10 genes correlated with disease activity according to the SLEDAI. The most striking correlation (P Ͻ 0.001, r ϭ 0.55) was found with the formyl peptide receptor-like 1 protein that mediates chemotactic activities of defensins. Therefore, while the IFN signature confirms the central role of this cytokine in SLE, microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Lynda Bennett

  • A. Karolina Palucka

  • Edsel Arce

  • Victoria Cantrell

  • Josef Borvak

  • Jacques Banchereau

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free