Hyaluronic acid (HA) has been crosslinked in solution with glutaraldehyde (GTA), 1-ethyl-3-(3-dime- thylaminopropyl) carbodiimide (EDC), poly(ethylene gly- col) diglycidylether (EX 810), and divinyl sulfone (DVS) to form hydrogels. Flory-Rehner calculations were used to determine molecular weight between crosslinks (Mc), the crosslink density (Ve), and mesh size (e)of crosslinked hydrogels after 24-h swelling in distilled water. Gener- ally, lower molecular weight films gave rise to decreased molecular weights between crosslinks as well as increased effective crosslink densities and decreased mesh size. The effects of pH and salt concentration were evaluated. Use of lower molecular weight HA gave rise to decreased mo- lecular weights between crosslinks as well as increased effective crosslink densities and decreased mesh size. Water diffusion coefficients were measured for DVS and GTA hydrogels and were found to be 1.4 3 10210 and 1.8 3 10210 m2 s21. Autocrosslinked and HA polyethylenei- mine gels were also produced but had very limited stabil- ities compared with the covalently crosslinked materi- als. ?
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