JC virus evolution and its association with human populations

  • Shackelton L
  • Rambaut A
  • Pybus O
 et al. 
  • 2

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

The ubiquitous human polyomavirus JC (JCV) is a small double-stranded DNA virus that establishes a persistent infection, and it is often transmitted from parents to children. There are at least 14 subtypes of the virus associated with different human populations. Because of its presumed codivergence with humans, JCV has been used as a genetic marker for human evolution and migration. Codivergence has also been used as a basis for estimating the rate of nucleotide substitution in JCV. We tested the hypothesis of host-virus codivergence by (i) performing a reconciliation analysis of phylogenetic trees of human and JCV populations and (ii) providing the first estimate of the evolutionary rate of JCV that is independent from the assumption of codivergence. Strikingly, our comparisons of JCV and human phylogenies provided no evidence for codivergence, suggesting that this virus should not be used as a marker for human population history. Further, while the estimated nucleotide substitution rate of JCV has large confidence intervals due to limited sampling, our analysis suggests that this virus may evolve nearly two orders of magnitude faster than predicted under the codivergence hypothesis.

Author-supplied keywords

  • *Evolution
  • *Phylogeny
  • *Population Groups/genetics
  • DNA
  • Evolution
  • Genetics
  • Genotype
  • Humans
  • JC Virus
  • JC Virus/classification/*genetics
  • JC Virus: classification
  • JC Virus: genetics
  • Mitochondrial
  • Mitochondrial/genetics
  • Mitochondrial: genetics
  • Molecular
  • Phylogeny
  • Point Mutation
  • Population
  • Population Groups
  • Population Groups: genetics
  • Viral
  • Viral/genetics
  • Viral: genetics

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Laura A Shackelton

  • Andrew Rambaut

  • Oliver G Pybus

  • Edward C Holmes

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free