Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia

  • Lear M
  • Simon O
  • Foley T
 et al. 
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(+/-)-Laetirobin (1) was isolated as a cytostatic lead from Laetiporus sulphureus growing parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-immunoaffinity system. Using an LC/MS procedure, milligram quantities of (+/-)-laetirobin (1) were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed by NMR spectroscopy. Preliminary cellular studies indicated that (+/-)-laetirobin (1) rapidly enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis.

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  • Martin J. Lear

  • Oliver Simon

  • Timothy L. Foley

  • Michael D. Burkart

  • Thomas J. Baiga

  • Joseph P. Noel

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