Liver cell therapy and tissue engineering for transplantation

  • Vacanti J
  • Kulig K
  • 46


    Mendeley users who have this article in their library.
  • 15


    Citations of this article.


Liver transplantation remains the only definitive treatment for liver failure and is available to only a tiny fraction of patients with end-stage liver diseases. Major limitations for the procedure include donor organ shortage, high cost, high level of required expertise, and long-term consequences of immune suppression. Alternative cell-based liver therapies could potentially greatly expand the number of patients provided with effective treatment. Investigative research into augmenting or replacing liver function extends into three general strategies. Bioartificial livers (BALs) are extracorporeal devices that utilize cartridges of primary hepatocytes or cell lines to process patient plasma. Injection of liver cell suspensions aims to foster organ regeneration or provide a missing metabolic function arising from a genetic defect. Tissue engineering recreates the organ in vitro for subsequent implantation to augment or replace patient liver function. Translational models and clinical trials have highlighted both the immense challenges involved and some striking examples of success. © 2014.

Author-supplied keywords

  • Hepatocytes
  • Liver transplantation alternatives
  • Organ engineering
  • Regenerative medicine
  • Stem cells
  • Tissue engineering
  • Xenotransplantation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Joseph P. Vacanti

  • Katherine M. Kulig

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free