Liver enzymes and clustering cardiometabolic risk factors in European adolescents: The HELENA study

  • Labayen I
  • Ruiz J
  • Ortega F
 et al. 
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OBJECTIVES: This study aimed to explore the associations of liver biomarkers with cardiometabolic risk factors and their clustering, and to provide reference values (percentiles) and cut-off points for liver biomarkers associated with high cardiometabolic risk in European adolescents. METHODS: Alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate aminotransferase to ALT ratio (AST/ALT), waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol and insulin were measured in 1084 adolescents. We computed a continuous cardiometabolic risk score and defined the high cardiometabolic risk. RESULTS: Higher ALT and GGT and lower AST/ALT were associated with adiposity and with the number of adverse cardiometabolic risk factors (Ps 

Author-supplied keywords

  • Liver
  • adolescents
  • cardiometabolic risk factors
  • obesity

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  • I. Labayen

  • J. R. Ruiz

  • F. B. Ortega

  • C. L. Davis

  • G. Rodríguez

  • M. González-Gross

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