Measuring compliance with drug regimens after renal transplantation: Comparison of self-report and clinician rating with electronic monitoring

  • Butler J
  • Peveler R
  • Roderick P
 et al. 
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Abstract

Nonadherence to immunosuppressants in renal transplant recipients is a major factor affecting graft survival, but it is difficult to detect accurately in clinical practice. Adherence was measured in 153 adult renal transplant recipients using self-report questionnaires and interview, clinician rating, and cyclosporine levels. The sensitivity and specificity of these measures were determined by comparison with electronic monitoring in a randomly selected subsample of 58 subjects. Measures of adherence in current clinical use do not perform well when tested against electronic monitoring. Self-report at a confidential interview was the best measure of adherence for the detection of both missed doses and erratic timing of medication. However, the use of a confidential interview is not directly applicable to a clinical setting. Further research on how best to facilitate disclosure in clinical settings may be the best way to develop adherence measures for use in routine practice.

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Authors

  • Janet A. Butler

  • Robert C. Peveler

  • Paul Roderick

  • Robert Horne

  • Juan C. Mason

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