Mechanisms of fibroblast cell therapy for dystrophic epidermolysis bullosa: High stability of collagen VII favors long-term skin integrity

  • Kern J
  • Loeckermann S
  • Fritsch A
 et al. 
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Abstract

Here, we report on the first systematic long-term study of fibroblast therapy in a mouse model for recessive dystrophic epidermolysis bullosa (RDEB), a severe skin-blistering disorder caused by loss-of-function of collagen VII. Intradermal injection of wild-type (WT) fibroblasts in >50 mice increased the collagen VII content at the dermal-epidermal junction 3.5- to 4.7-fold. Although the active biosynthesis lasted

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Authors

  • Johannes S. Kern

  • Stefan Loeckermann

  • Anja Fritsch

  • Ingrid Hausser

  • Wera Roth

  • Thomas M. Magin

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