Mechanisms of roof plate formation in the vertebrate CNS

  • Chizhikov V
  • Millen K
  • 106


    Mendeley users who have this article in their library.
  • 53


    Citations of this article.


The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development.

Author-supplied keywords

  • Animals
  • Body Patterning
  • Body Patterning: physiology
  • Bone Morphogenetic Proteins
  • Bone Morphogenetic Proteins: metabolism
  • Cell Differentiation
  • Cell Differentiation: physiology
  • Cell Lineage
  • Cell Lineage: physiology
  • Central Nervous System
  • Central Nervous System: cytology
  • Central Nervous System: embryology
  • Central Nervous System: physiology
  • Developmental
  • Developmental: physiology
  • Embryo
  • Embryonic Induction
  • Embryonic Induction: physiology
  • Gene Expression Regulation
  • Homeodomain Proteins
  • Homeodomain Proteins: metabolism
  • Neural Crest
  • Neural Crest: embryology
  • Neural Crest: physiology
  • Neurons
  • Neurons: physiology
  • Nonmammalian
  • Vertebrates

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Victor V Chizhikov

  • Kathleen J Millen

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free