Memantine: A comprehensive review of safety and efficacy

  • Kavirajan H
  • 32

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Background: Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate glutamate receptor. It is now approved only for treatment of moderate-to-severe Alzheimer's disease (AD). However, as a growing body of evidence indicates that disturbed glutamate neurotransmission may be central to the pathophysiology of such conditions as obesity, schizophrenia, depression, substance abuse, pain disorders and glaucoma, clinical trials have explored the role of memantine in these and other disorders. Objective: To provide a comprehensive review of the safety and efficacy of memantine across the range of clinical applications in which it has been studied. Methods: A search was done on Pubmed using keyword 'memantine' to identify clinical trials of memantine. Results/conclusion: At present, clinical trial evidence supports the use of memantine in only moderate-to-severe AD. Preliminary studies suggest benefit in frontotemporal dementia, alcohol dependence, post-traumatic stress disorder, headache and obesity, but rigorous clinical trials are needed to confirm these results. Available data indicate that across a range of clinical applications, memantine is a safe and well-tolerated drug. (copyright) 2009 Informa UK Ltd All rights reserved.

Author-supplied keywords

  • Alzheimer disease
  • Human immunodeficiency virus infection
  • Huntington chorea
  • Medline
  • Mini Mental State Examination
  • acetazolamide
  • acquired immune deficiency syndrome
  • aging
  • agitation
  • alcoholism
  • antiretrovirus agent
  • anxiety
  • attention deficit disorder
  • auditory hallucination
  • autism
  • axura
  • backache
  • balance disorder
  • balance impairment
  • binge eating disorder
  • bipolar disorder
  • clinical trial
  • clozapine
  • cocaine dependence
  • cognitive defect
  • confusion
  • congenital nystagmus
  • constipation
  • cramping
  • dextromethorphan
  • diabetic neuropathy
  • diabetic retinopathy
  • diarrhea
  • digoxin
  • disorientation
  • dizocilpine
  • dizziness
  • donepezil
  • drug dependence
  • drug dose reduction
  • drug efficacy
  • drug safety
  • drug tolerability
  • drug withdrawal
  • ebixa
  • escitalopram
  • euphoria
  • fatigue
  • frontotemporal dementia
  • gabapentin
  • galantamine
  • gastrointestinal symptom
  • glaucoma
  • glibenclamide
  • haloperidol
  • headache
  • human
  • hypertension
  • infection
  • insomnia
  • lethargy
  • lorazepam
  • major depression
  • memantine
  • memory disorder
  • mk 801
  • multiinfarct dementia
  • muscle cramp
  • naloxone
  • namenda
  • nausea and vomiting
  • neurologic disease
  • neuropathic pain
  • nonhuman
  • obesity
  • obsessive compulsive disorder
  • olanzapine
  • opiate addiction
  • paroxetine
  • pervasive developmental disorder not otherwise spe
  • phantom pain
  • photosensitivity
  • postherpetic neuralgia
  • posttraumatic stress disorder
  • review
  • rhinopharyngitis
  • risperidone
  • rivastigmine
  • schizoaffective psychosis
  • schizophrenia
  • sedation
  • side effect
  • somnolence
  • tobacco dependence
  • topiramate
  • toxicity
  • transformed migraine
  • tremor
  • upper respiratory tract infection
  • urine incontinence
  • vertigo
  • vital sign
  • warfarin
  • weight gain
  • weight reduction
  • zonisamide

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • H. Kavirajan

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free