This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships between alterations in lipid composition, regulation of membrane lipid biogenesis, and cellular secretory function are discussed. Copyright ©2009 by the American Society for Biochemistry and Molecular Biology, Inc.
CITATION STYLE
Fagone, P., & Jackowski, S. (2009, April). Membrane phospholipid synthesis and endoplasmic reticulum function. Journal of Lipid Research. https://doi.org/10.1194/jlr.R800049-JLR200
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