A membrane slurry reduces postoperative adhesions in rat models of abdominal surgery

  • Greenawalt K
  • Colt M
  • Corazzini R
 et al. 
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Background: Sodium hyaluronate and carboxymethylcellulose (HA-CMC) membrane is an effective barrier material for limiting postoperative adhesions, but can be difficult to apply in certain situations due to its physical properties. We tested whether HA-CMC membrane hydrated in saline (slurry) is an effective alternative to HA-CMC membrane for preventing surgical adhesions in rat models of abdominal surgery. Materials and methods: All studies were performed in rat cecal abrasion or sidewall defect models of adhesion formation. Adhesions were examined 7 d after surgery. In separate studies, the effects of variations in slurry composition, volume, and site of application on anti-adhesive properties were studied and compared with untreated controls. Finally, the effectiveness of HA-CMC membrane slurry for preventing adhesions was compared with that of conventional HA-CMC membrane. Results: Application of HA-CMC membrane slurry to traumatized tissue resulted in a significant reduction in the incidence of adhesions compared with untreated controls in both rat surgery models. Slurry was equally effective when applied in low and high film-to-volume formulations, but had minimal effect when applied in a small volume or at a location distal to the injury. Comparison of HA-CMC membrane slurry and conventional HA-CMC membrane indicated similar efficacy for reducing postoperative adhesions. Conclusions: In rat models of abdominal surgery, HA-CMC membrane slurry reduced postoperative adhesion formation and may be an effective alternative for HA-CMC membrane in situations where its use is limited by its physical properties. © 2011 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • abdominal surgery
  • adhesions
  • cecal abrasion model
  • sidewall defect model
  • sodium hyaluronate and carboxymethylcellulose membrane

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  • Keith E. Greenawalt

  • M. Jude Colt

  • Rubina L. Corazzini

  • Megan C. Krauth

  • Lena Holmdahl

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