Membraneless microseparation by asymmetry in curvilinear laminar flows

  • Seo J
  • Lean M
  • Kole A
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Abstract

Membraneless microseparation by asymmetric inertial migration is studied in curvilinear laminar flows and evidence of the microseparation is presented. Along a curvilinear laminar flow, transverse particle migration involves competition between three shear-flow effects; the tubular pinch effect, centrifugal force, and Dean's vortex. Equilibrating control of migration allows for particle separation to different outlets. No filter-media or external force is necessary for the microseparation utilizing only shear-flow characteristics. A double-spiral design effectively controls the migration to optimize microseparation. The concentration ratio of 10 μm beads from the two different outlets was 660 times at 92 mm/s of flow velocity. This new technology has great potential for high-throughput and low cost in bio-agent and particulate separation at both macro and micro scales. © 2007 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Asymmetric tubular pinch effect
  • Curvilinear laminar flow
  • Dean's vortex
  • Membraneless separation
  • Microfiltration
  • Microfluidics
  • Particle separation
  • Spiral channel

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Authors

  • Jeonggi Seo

  • Meng H. Lean

  • Ashutosh Kole

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