Membraneless microseparation by asymmetric inertial migration is studied in curvilinear laminar flows and evidence of the microseparation is presented. Along a curvilinear laminar flow, transverse particle migration involves competition between three shear-flow effects; the tubular pinch effect, centrifugal force, and Dean's vortex. Equilibrating control of migration allows for particle separation to different outlets. No filter-media or external force is necessary for the microseparation utilizing only shear-flow characteristics. A double-spiral design effectively controls the migration to optimize microseparation. The concentration ratio of 10 μm beads from the two different outlets was 660 times at 92 mm/s of flow velocity. This new technology has great potential for high-throughput and low cost in bio-agent and particulate separation at both macro and micro scales. © 2007 Elsevier B.V. All rights reserved.
CITATION STYLE
Seo, J., Lean, M. H., & Kole, A. (2007). Membraneless microseparation by asymmetry in curvilinear laminar flows. Journal of Chromatography A, 1162(2 SPEC. ISS.), 126–131. https://doi.org/10.1016/j.chroma.2007.05.110
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