The ultimate goal of all cardiovascular clinical research should be to reduce the morbidity and mortality from cardiovascular diseases at an acceptable cost. In no area of medicine has clinical research led to a greater change in medical care than in the management of acute myocardial infarction (AMI). We now try to accomplish early coronary reperfusion in all ST-elevation MIs and administer a combination of drugs in the post-infarction period to halt or slow the progressive remodeling process that leads to heart failure and shortened survival1. Clinical trials have documented the dramatic efficacy of these therapeutic interventions on morbidity and mortality2-5.
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