Metabolomics in angiotensin II-induced cardiac hypertrophy

  • Mervaala E
  • Biala A
  • Merasto S
 et al. 
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Abstract

Angiotensin II (Ang II) induces mitochondrial dysfunction. We tested whether Ang II alters the "metabolomic" profile. We harvested hearts from 8-week-old double transgenic rats harboring human renin and angiotensinogen genes (dTGRs) and controls (Sprague-Dawley), all with or without Ang II type 1 receptor (valsartan) blockade. We used gas chromatography coupled with time-of-flight mass spectrometry to detect 247 intermediary metabolites. We used a partial least-squares discriminate analysis and identified 112 metabolites that differed significantly after corrections (false discovery rate q

Author-supplied keywords

  • Angiotensin II
  • Hypertension
  • Hypertrophy
  • Metabolomics
  • Oxidative stress

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Authors

  • Eero Mervaala

  • Agnieszka Biala

  • Saara Merasto

  • Juha Lempiäinen

  • Ismo Mattila

  • Essi Martonen

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