Metabolomics in angiotensin II-induced cardiac hypertrophy

  • Mervaala E
  • Biala A
  • Merasto S
 et al. 
  • 47


    Mendeley users who have this article in their library.
  • 28


    Citations of this article.


Angiotensin II (Ang II) induces mitochondrial dysfunction. We tested whether Ang II alters the "metabolomic" profile. We harvested hearts from 8-week-old double transgenic rats harboring human renin and angiotensinogen genes (dTGRs) and controls (Sprague-Dawley), all with or without Ang II type 1 receptor (valsartan) blockade. We used gas chromatography coupled with time-of-flight mass spectrometry to detect 247 intermediary metabolites. We used a partial least-squares discriminate analysis and identified 112 metabolites that differed significantly after corrections (false discovery rate q

Author-supplied keywords

  • Angiotensin II
  • Hypertension
  • Hypertrophy
  • Metabolomics
  • Oxidative stress

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Eero Mervaala

  • Agnieszka Biala

  • Saara Merasto

  • Juha Lempiäinen

  • Ismo Mattila

  • Essi Martonen

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free